Cancer patients often face a range of symptoms from both disease progression and the side effects of treatments like radiation and chemotherapy, significantly impacting their quality of life (QOL). Among these, fatigue is one of the most prevalent and debilitating symptoms—often having a greater effect on daily functioning than pain.
Recent studies have shown that intravenous (IV) vitamin C may help reduce several cancer- and chemotherapy-related symptoms, including fatigue, insomnia, nausea, appetite loss, and pain. Research also suggests improvements in overall health and in physical, cognitive, emotional, social, and role-related functioning following IV vitamin C therapy.
Our study indicates that high-dose intravenous vitamin C (IVC), particularly at doses exceeding 30 g, may produce an acute blood pressure lowering effect, especially in individuals with prehypertension and a normal BMI. Additionally, the findings reveal a significant and clinically relevant blood pressure elevating effect associated with intravenous vitamin B12 (IVB12), highlighting the importance of routine blood pressure monitoring during intravenous therapy in clinical settings.
Intravenous vitamin C significantly reduced fatigue within two hours, with the effects lasting for up to 24 hours. No notable differences in adverse events were observed between the treatment and control groups. Overall, high-dose intravenous vitamin C was found to be a safe and effective intervention for alleviating fatigue in this study.
Collectively, vitamin C has been shown to enhance early in vivo antiviral immune responses particularly against the influenza virus by promoting increased production of interferons α and β (IFN-α/β).
Vitamin C administration in patients with congestive heart failure (CHF) has been shown to suppress endothelial cell (EC) apoptosis in vivo, potentially contributing to the observed improvements in endothelial function associated with its supplementation.
If similar effects are observed in individuals with atherosclerosis or related risk factors, Vitamin C supplementation could emerge as a promising therapeutic option for cardiovascular disease.
Supplementation with vitamins E and C demonstrated a mild anti-inflammatory effect in cases of chronic degenerative aortic stenosis (AS).
Daily antioxidant supplementation particularly with vitamin C significantly reduced plasma F2-isoprostane (F2IsoP) levels, an oxidative stress biomarker, in passive smokers. Subjects receiving vitamin C and the antioxidant mixture showed reductions of 17.2 pmol/L (P = 0.0105) and 19.2 pmol/L (P = 0.0083), respectively, compared to the placebo group (11.4% and 12.7% decreases).
Findings indicate that dietary supplementation with vitamins E and C may provide protective benefits for adults with asthma exposed to air pollution.
Overall, insufficient intake and low levels of certain vitamins and minerals can weaken the immune system, increasing vulnerability to infections and worsening malnutrition.
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